УДК 577.112, 577.181
Authors:
Tikhonov S. L.,
Styagova P. S.,
Tikhonova N. V.,
Styagov N.N.
Annotation. This paper presents a study of an antioxidant peptide with the amino acid sequence CTKSICTKKTLRTCPPIC, developed using the molecular peptide transplantation (MPT) method. A virtual in silico screening was conducted on the ADMETlab 3 platform, which made it possible to assess the metabolic stability of the peptide in the human body and its interaction with cytochrome P450 enzymes. The absence of inhibitory and substrate properties with respect to the main enzymes of the P450 group (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP2C8) metabolizing drugs has been established. Not being an inhibitor and substrate for the above enzymes, the peptide remains stable in the human body with oral administration and does not enter into undesirable drug interactions. This, in turn, indicates the bioavailability, rapid digestibility and low toxicity of this biologically active compound for humans.
Keywords: peptide, antioxidant peptide, virtual screening, drug metabolism, biotechnology
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